Abstract

The aim of this study was an immunohistological investigation of the TGFß (transforming growth factor), BMP6 (bone morphogenetic protein), MMPs 1-3 (metalloproteinases) and TIMP-1 (tissue inhibitors of metalloproteinases) in the following tissue compartments: maxillary sinus epithelium-mucosa - maxillary bone - oral mucosa as well as a radiometric assessment of the anterior and posterior segments of maxillary bone. We were able to confirm the involvement of epithelium- mucosa in the growth and formation of maxillary sinuses and their pneumatisation in physiological conditions as well as in chronic allergic sinusitis. This is connected with the intense synthesis of MMP proteases, which, like in bones, regulates the turnover and rebuilding process of surrounding soft tissues. This is true for the control samples as well as for the samples taken from the cases of allergic maxillary sinusitis during surgery.

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