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Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti-inflammatory and analgesic activities

Pau, Amedeo and Boatto, Gianpiero and Cerri, Riccardo and Palagiano, Francesco and Filippelli, Walter and Falcone, Giuseppe and Lampa, Enrico (1998) Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti-inflammatory and analgesic activities. Il Farmaco, Vol. 53 (3), p. 233-240. ISSN 0014-827X. Article.

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DOI: 10.1016/S0014-827X(98)00016-0


Two series of 1-methyl-4-(N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-(N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated in order to obtain a more exhaustive knowledge of the structure-activity relationship.

Item Type:Article
ID Code:5270
Uncontrolled Keywords:Piperidinamides, anti-inflammatory agents, analgesic agents
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Copyright Holders:© 1998 Published by Éditions scientifiques et médicales Elsevier SAS
Deposited On:20 Dec 2010 18:52

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