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Monitoring of oxytetracycline in ovine milk by high-performance liquid chromatography

Boatto, Gianpiero and Pau, Amedeo and Palomba, Michele Francesco Luigi and Arenare, Loredana and Cerri, Riccardo (1999) Monitoring of oxytetracycline in ovine milk by high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, Vol. 20 (1-2), p. 321-326. eISSN 1873-264X. Article.

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DOI: 10.1016/S0731-7085(99)00050-3

Abstract

A method for ‘in vivo’ determination of the oxytetracyclin residues in ovine milk at low levels is described. Two groups of Sardinian breed sheep were treated with a dose of oxytetracycline by intramammary infusion and intramuscular administration, respectively. Oxytetracycline residues in extracts obtained from a preliminary cleanup procedure, were detected by an isocratic high-performance liquid chromatography (HPLC) method. Linear calibration plots were obtained over a large concentration range of 1 mg ml−1–10 ng ml−1, with correlation coefficients higher than 0.996. Recoveries between 85.8 and 98.9% were obtained. Limit of detection (LOD) and limit of determination (LOQ) were 5.2 and 17.5 ng ml−1, respectively. This method would be useful for routine monitoring of oxytetracycline residues in ovine dairy milk.

Item Type:Article
ID Code:5267
Status:Published
Refereed:Yes
Uncontrolled Keywords:Oxytetracycline, in vivo monitoring, trace amounts, reversed-phase liquid chromatography, milk
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier
eISSN:1873-264X
Deposited On:20 Dec 2010 13:56

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