Synthesis of substituted N-(4-piperidyl)-N-(3-pyridyl)amides with antiarrhythmic activity: note 1.

Pau, Amedeo and Asproni, Battistina and Boatto, Gianpiero and Palomba, Michele Francesco Luigi and Cerri, Riccardo and Rimoli, Maria Grazia and Filippelli, Walter and Falcone, Giuseppe (2000) Synthesis of substituted N-(4-piperidyl)-N-(3-pyridyl)amides with antiarrhythmic activity: note 1. Die Pharmazie, Vol. 55 (12), p. 892-895. ISSN 0031-7144. Article.

Full text not available from this repository.

Alternative URLs:

Abstract

The synthesis of analogues of N,2-diphenyl-N-(4-piperidyl)acetamide endowed with antiarrhythmic activity is reported. Benzoyl, cinnamoyl, acetyl and propionyl groups replace the phenacyl group as N-acyl substituent, while pyridine replaces benzene as aromatic ring bound to the amide nitrogen. The title compounds were evaluated for antiarrhythmic activity on experimental arrhythmias induced by aconitine in rats. The presence of a n-propyl chain and an unsubstituted cinnamoyl moiety (1j) gives the highest protection against aconitine induced extrasystoles while the best efficacy against lethal effects is due to the presence of a n-propyl chain and an acetyl moiety (1m).

Item Type:	Article
ID Code:	5265
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Piperidyl amides, pyridyl amides, antiarrythmic activity
Subjects:	Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:	Govi-Verlag
ISSN:	0031-7144
Deposited On:	20 Dec 2010 13:34

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page