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Synthesis of N-[4-(propyl)cyclohexyl]-amides with anti-inflammatory and analgesic activities

Pau, Amedeo and Boatto, Gianpiero and Asproni, Battistina and Palomba, Michele Francesco Luigi and Auzzas, Luciana and Cerri, Riccardo and Palagiano, Francesco and Filippelli, Walter and Falcone, Giuseppe and Motola, Giulia (2000) Synthesis of N-[4-(propyl)cyclohexyl]-amides with anti-inflammatory and analgesic activities. Il Farmaco, Vol. 55 (6-7), p. 439-447. ISSN 0014-827X. Article.

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DOI: 10.1016/S0014-827X(00)00063-X

Abstract

Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a–h, 7a–h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure–activity relationships.

Item Type:Article
ID Code:5263
Status:Published
Refereed:Yes
Uncontrolled Keywords:N-[4-(propyl)cyclohexyl]-amides, anti-inflammatory agents, analgesic agents
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Elsevier
ISSN:0014-827X
Copyright Holders:© 2000 Elsevier Science
Deposited On:20 Dec 2010 12:14

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