Pau, Amedeo and Boatto, Gianpiero and Asproni, Battistina and Palomba, Michele Francesco Luigi and Auzzas, Luciana and Cerri, Riccardo and Palagiano, Francesco and Filippelli, Walter and Falcone, Giuseppe and Motola, Giulia (2000) Synthesis of N-[4-(propyl)cyclohexyl]-amides with anti-inflammatory and analgesic activities. Il Farmaco, Vol. 55 (6-7), p. 439-447. ISSN 0014-827X. Article.
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Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a–h, 7a–h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure–activity relationships.
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