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Ultrastructural anatomy of contracted capsules around textured implants in augmented breasts

Rubino, Corrado and Mazzarello, Vittorio Lorenzo Giuseppe and Farace, Francesco and D'Andrea, Francesco and Montella, Andrea Costantino Mario and Fenu, Grazia and Campus, Gian Vittorio (2001) Ultrastructural anatomy of contracted capsules around textured implants in augmented breasts. Annals of Plastic Surgery, Vol. 46 (2), p. 95-102. eISSN 1536-3708. Article.

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Abstract

The development of a capsule around an implant is part of the physiological response to a foreign body. Capsular contracture is the most specific and frustrating complication of augmentation mammaplasty, and a lot of studies have been devoted to it. The aim of the current study is to examine the fine architecture of the contracted capsule around textured implants in humans. Eight capsules from augmented and contracted breasts with gel-filled, textured-surface silicone implants were studied after standard preparation for light and scanning electron microscopy, and after partial digestion in sodium hydroxide. Two capsules from contracted breasts around smooth implants and two noncontracted capsules around textured implants were prepared and studied in the same fashion as controls. A multilayer structure of the contracted capsule was seen, and the architecture of the various layers is described. The inner surface presents irregular craterlike depressions. The arrangement of collagen fibers varies in capsule layers. The effect of a textured-surface implant on the mechanism of capsule contraction based on the observed capsular architecture is that only part of the capsule is effective mechanically in producing a contracting force. A thin vascular layer was identified near the inner surface in contracted capsules around textured implants, and the authors' think that this layer is probably the key structure in the histological development and growth of the capsule.

Item Type:Article
ID Code:524
Status:Published
Refereed:Yes
Uncontrolled Keywords:Pathophysiology, plastic surgery, implant, mammaplasty, mammary gland, etiopathogenesis, biomaterial, biocompatibility, siloxane polymer, mammary gland diseases, biomedical engineering
Subjects:Area 06 - Scienze mediche > MED/19 Chirurgia plastica
Area 05 - Scienze biologiche > BIO/16 Anatomia umana
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Dermatologia
Publisher:Lippincott Williams & Wilkins
eISSN:1536-3708
Deposited On:18 Aug 2009 10:02

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