Tomasi, Paolo and Fanciulli, Giuseppe and Delitala, Giuseppe (2005) Successful treatment of retrograde ejaculation with the α1-adrenergic agonist methoxamine: case study. International Journal of Impotence Research, Vol. 17 (3), p. 297-299. eISSN 1476-5489. Article.
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We treated two patients affected by retrograde ejaculation (RE) with the pure α 1-adrenergic agonist methoxamine; the drug was self-administered intramuscularly by the patients 30 min prior to intercourse or masturbation. A previous trial with oral imipramine had been ineffective in both patients. Sperm count increased substantially, particularly in the first patient who had insulin-dependent diabetes and was seeking fertility. In this patient, total ejaculated sperm increased from 22 millions to 488 and 419.5 millions on two different occasions, with good motility; two clinical pregnancies were obtained in the partner of this patient after 3 and 4 months of treatment, respectively. The second patient did not desire fertility. In both patients, no side effects were seen except for slight piloerection; blood pressure values increased slightly, and heart rate was unchanged. We conclude that self-administered methoxamine can be a useful, noninvasive and inexpensive treatment of RE, when oral agents are ineffective.
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