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Anti-inflammatory and analgesic amides: new developments

Palomba, Michele Francesco Luigi and Pau, Amedeo and Boatto, Gianpiero and Asproni, Battistina and Auzzas, Luciana and Cerri, Riccardo and Arenare, Loredana and Filippelli, Walter and Falcone, Giuseppe and Motola, Giulia (2000) Anti-inflammatory and analgesic amides: new developments. Archiv der Pharmazie, Vol. 333 (1), p. 17-26. eISSN 1521-4184. Article.

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DOI: 10.1002/(SICI)1521-4184(200001)333:1<17::AID-ARDP17>3.0.CO;2-0


A series of substituted N-cycloalkyl benzamides, cinnamamides, and indole-3-carboxamides were synthesized and evaluated for their analgesic, antiinflammatory activities as well as for their gastrointestinal irritation liability. Indomethacin was used as reference drug in both tests. Compounds 1k, 1b, 1h, 1j, and 1g were the most active in the antiinflammatory paw edema inhibition test, with a sharply dose-dependent effect. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 5a followed by 3a, but many other compounds were found to have a non-negligible potency. Even in this case, the effect was dose dependent.

Item Type:Article
ID Code:5223
Uncontrolled Keywords:Analgesic amides, anti-inflammatory amides, substituted N-cycloalkyl benzamides, cinnamamides, and indole-3-carboxamides
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Deposited On:10 Dec 2010 16:43

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