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Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro

Franconi, Flavia and Miceli, Mauro and Alberti, Luisa and Boatto, Gianpiero and Coinu, Rita and Demontis, Maria Graziella and Tagliamonte, Alessandro (2001) Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. Thrombosis Research, Vol. 102 (3), p. 255-260. ISSN 0049-3848. Article.

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DOI: 10.1016/S0049-3848(01)00249-3

Abstract

Endogenous formation of gamma-hydroxybutyric acid (GHB) has been described in humans. It is considered to be a neurotransmitter and/or neuromodulator although its precise physiological role remains unclear. This molecule is used in the treatment of alcoholism and alcohol withdrawal.
GHB, at least in central nervous system, has ethanol-like activities and it is well-known that ethanol decreases platelet function. However, there are no information regarding the GHB and its effect on platelet function. Therefore, the goal of the study was to investigate the most notable GHB effects on human platelet aggregation in vitro.

Item Type:Article
ID Code:5221
Status:Published
Refereed:Yes
Uncontrolled Keywords:GABA, human platelet
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Pergamon
ISSN:0049-3848
Copyright Holders:© 2001 Elsevier Science
Deposited On:10 Dec 2010 16:13

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