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Synthesis of amides with anti-inflammatory and analgesic activities

Pau, Amedeo and Cerri, Riccardo and Boatto, Gianpiero and Palomba, Michele Francesco Luigi and Pintore, Giorgio Antonio Mario and Filippelli, Walter and Falcone, Giuseppe and Palagiano, Francesco and Rossi, Francesco (1997) Synthesis of amides with anti-inflammatory and analgesic activities. Il Farmaco, Vol. 52 (2), p. 93-98. ISSN 0014-827X. Article.

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A series of N-Aroyl-cyclohexyl- and cyclohexenylamides 3- or 4-methylsubstituted were synthesized and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability. One compound, N-benzoyl-4-methyl-cyclohexylamide 6a, possessed an anti-inflammatory activity comparable to that of indomethacin.

Item Type:Article
ID Code:5218
Uncontrolled Keywords:Amides, anti-inflammatory activity, analgesic activity
Subjects:Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Società chimica italiana
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:10 Dec 2010 13:51

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