Pau, Amedeo and Cerri, Riccardo and Boatto, Gianpiero and Palomba, Michele Francesco Luigi and Pintore, Giorgio Antonio Mario and Filippelli, Walter and Falcone, Giuseppe and Palagiano, Francesco and Rossi, Francesco (1997) Synthesis of amides with anti-inflammatory and analgesic activities. Il Farmaco, Vol. 52 (2), p. 93-98. ISSN 0014-827X. Article.
A series of N-Aroyl-cyclohexyl- and cyclohexenylamides 3- or 4-methylsubstituted were synthesized and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability. One compound, N-benzoyl-4-methyl-cyclohexylamide 6a, possessed an anti-inflammatory activity comparable to that of indomethacin.
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