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NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway

Debidda, Marcella and Sanna, Bastiano and Cossu, Annalisa and Posadino, Anna Maria and Tadolini, Bruna and Ventura, Carlo and Pintus, Gianfranco (2003) NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway. International Journal of Oncology, Vol. 23 (2), p. 477-482. eISSN 1791-2423. Article.

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Abstract

Imidazolium trans-imidazole dimethyl sulfoxide tetrachlororuthenate (NAMI-A) is a new compound active against lung metastasis of solid metastasizing tumours. While its in vivo effect has been studied, the molecular insights that underlie its action are largely unknown. Among the possible pathways responsible for malignant transformation, PKC arose as one of the most promising targets for new antineoplastic drugs. We demonstrated the capability of NAMI-A of inhibiting PMA induced-PKC activity in ECV304 in a dose-dependent fashion. Furthermore, NAMI-A through modulation of PKC activity has been proved capable of reducing the phorbol ester induced expression of ornithine decarboxilase (ODC) gene and to abrogate the activation of the Raf/MEK/ERK pathway. Taken together these results suggest that many of the in vivo outcomes of NAMI-A treatment may be the result of a direct action on PKC.

Item Type:Article
ID Code:5177
Status:Published
Refereed:Yes
Uncontrolled Keywords:Ruthenium compounds, protein kinase C, ODC gene expression, mitogen-activated protein kinase
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Spandidos
eISSN:1791-2423
Deposited On:03 Dec 2010 10:15

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