Carvedilol, a β adrenoceptor blocker with chelating properties: a copper ‘superdimer’ based on dimetal units

Zoroddu, Maria Antonietta and Grepioni, Fabrizia and Franconi, Flavia (2003) Carvedilol, a β adrenoceptor blocker with chelating properties: a copper ‘superdimer’ based on dimetal units. Journal of Inorganic Biochemistry, Vol. 95 (4), p. 315-320. ISSN 0162-0134. Article.

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DOI: 10.1016/S0162-0134(03)00130-2

Abstract

Copper(II) complexes of carvedilol molecule, (carvH): 1-[carbazolyl-(4)-oxyl]-3-[(2-methoxyphenoxyethyl)-amino]-2-propanol, were synthesized and characterized with respect to their structural and spectroscopic properties. The crystal structure of [Cu(Carv)Cl(MeOH)]₂•4MeOH complex revealed that the molecule chelates two Cu(II) ions via the N and O atoms belonging to the amino and propanol moiety, respectively. The coordination behaviour of carvedilol studied by ¹H nuclear magnetic resonance (NMR, 1-D and 2-D-COSY) spectroscopy in dimethyl sulfoxide solution at room temperature, allowed us to obtain structural information and to identify the donor atoms involved in the coordination process in solution.

Item Type:	Article
ID Code:	5175
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Carvedilol, Cu(II), chelating, antioxidant drug
Subjects:	Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:	001 Università di Sassari > 01 Dipartimenti > Chimica 001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:	Elsevier Science
ISSN:	0162-0134
Deposited On:	03 Dec 2010 10:09

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