Sotgiu, Stefano and Mameli, Giuseppe and Serra, Caterina and Zarbo, Ir and Arru, Giannina and Dolei, Antonina (2010) Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis. Multiple Sclerosis Journal, Vol. 16 (10), p. 1248-1251. eISSN 1477-0970. Article.
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Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.
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