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Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis

Sotgiu, Stefano and Mameli, Giuseppe and Serra, Caterina and Zarbo, Ir and Arru, Giannina and Dolei, Antonina (2010) Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis. Multiple Sclerosis Journal, Vol. 16 (10), p. 1248-1251. eISSN 1477-0970. Article.

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DOI: 10.1177/1352458510376956

Abstract

Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.

Item Type:Article
ID Code:5160
Status:Published
Refereed:Yes
Uncontrolled Keywords:EDSS, MSRV, multiple sclerosis, prognosis, retrovirus, secondary progressive
Subjects:Area 06 - Scienze mediche > MED/28 Malattie odontostomatologiche
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:SAGE Publications
eISSN:1477-0970
Copyright Holders:© The Author(s) 2010
Deposited On:02 Dec 2010 12:53

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