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Modifications of poly(o-phenylenediamine) permselective layer on Pt-Ir for biosensor application in neurochemical monitoring

Kirwan, Sarah M. and Rocchitta, Gaia Giovanna Maria and McMahon, Colm P. and Craig, Jennifer D. and Killoran, Sarah J. and O’Brien, Kylie B. and Serra, Pier Andrea and Lowry, John P. and O’Neill, Robert D. (2007) Modifications of poly(o-phenylenediamine) permselective layer on Pt-Ir for biosensor application in neurochemical monitoring. Sensors, Vol. 7 (4), p. 420-437. ISSN 1424-8220. Article.

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DOI: 10.3390/s7040420

Abstract

Reports that globular proteins could enhance the interference blocking ability of the PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensor design, prompted this study where a variety of modifying agents were incorporated into PPD during its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteins and β-cyclodextrin, altered the polymer/modifier composite selectivity by affecting the sensitivity to both H2O2 (signal molecule in many enzyme-based biosensors) and the archetypal interference species, ascorbic acid. A comparison of electrochemical properties of Pt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploited in PPD-based biosensor design without significant loss of backward compatibility with studies involving pure Pt.

Item Type:Article
ID Code:5071
Status:Published
Refereed:Yes
Uncontrolled Keywords:Platinum-iridium electrodes, polymer electrosynthesis, cyclic voltammetry, amperometry, proteins, cyclodextrins, ascorbate, hydrogen peroxide, brain analysis
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:MDPI Publishing
ISSN:1424-8220
Publisher Policy:Depositato in conformità con la politica di copyright dell'Editore
Deposited On:29 Nov 2010 15:30

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