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Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo

O’Neill, Robert D. and Rocchitta, Gaia Giovanna Maria and McMahon, Colm P. and Serra, Pier Andrea and Lowry, John P. (2008) Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo. Trends in Analytical Chemistry, Vol. 27 (1), p. 78-88. ISSN 0165-9936. Article.

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DOI: 10.1016/j.trac.2007.11.008

Abstract

Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity and selectivity parameters, which allow development of the basic design in a systematic way in order to improve their performance and to diversify the analyte range of these novel probes of brain function.

Item Type:Article
ID Code:4990
Status:Published
Refereed:Yes
Uncontrolled Keywords:Ascorbic acid interference, brain monitoring, electropolymerization, glucose, glutamate, H2O2 permeability, polymer-modified electrode
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier
ISSN:0165-9936
Copyright Holders:© 2007 Elsevier
Deposited On:26 Nov 2010 16:45

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