Garson, Jeremy A. and Créange, Alain and Dolei, Antonina and Ferrante, Pasquale and Jouvin-Marche, Evelyne and Marche, Patrice N. and Rieger, François and Ruprech, Klemens and Saresella, Marina and Sotgiu, Stefano and Tedder, Richard and Perron, Herve (2005) MSRV, Syncytin and the role of endogenous retroviral proteins in demyelination. Multiple Sclerosis Journal, Vol. 11 (2), p. 249-250. eISSN 1477-0970. Article.
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A major study on the pathogenesis of multiple sclerosis was published in the October issue of Nature Neuroscience accompanied by a flurry of media reports. The study by Antony and colleagues describes the potential role of syncytin, a human endogenous retroviral glycoprotein, in the process of demyelination. We were impressed by the quality of the biochemical, immunohistological and neurobehavioural data presented by Antony et al .1 in support of the ‘retroviral hypothesis’ but dismayed to see that the authors had omitted to mention or reference the highly relevant and extensive pre-existing literature of at least thirty papers linking multiple sclerosis with this retroviral family.
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