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Increasing Incidence of Multiple Sclerosis in the Province of Sassari, Northern Sardinia

Pugliatti, Maura and Riise, Trond and Sotgiu, Alessandra Maria and Satta, Wanda Maria and Mannu, Luisella and Sanna, Giovanna and Rosati, Giulio (2005) Increasing Incidence of Multiple Sclerosis in the Province of Sassari, Northern Sardinia. Neuroepidemiology, Vol. 25 (3), p. 129-134. eISSN 1423-0208. Article.

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DOI: 10.1159/000086677

Abstract

Sardinia is a high-risk area for multiple sclerosis (MS), with prevalence rates of 150 per 100,000 population. The study included 689 MS patients (female-male ratio 2.6) with disease onset between 1965 and 1999 in the province of Sassari. The mean annual incidence rate increased significantly from 1.1 per 100,000 population in 1965–1969 to 5.8 in 1995–1999, with no significant difference for gender and province sub-areas. The mean age at onset increased significantly during the same period from 25.7 to 30.6 years, while the proportion of patients with progressive initial course declined over time. The marked increase of MS incidence and the change of MS clinical phenotype over time cannot be explained by ascertainment bias only, thus pointing to a corresponding change in the distribution of exogenous risk factors in this highly genetically stable population.

Item Type:Article
ID Code:4974
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, epidemiology, Sardinia
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Karger
eISSN:1423-0208
Deposited On:26 Nov 2010 11:14

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