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The Role of hereditary spastic paraplegia related genes in multiple sclerosis: a study of disease susceptibility and clinical outcome

De Luca, Giancarlo and Ramagopalan, Sreeram V. and Cader, Zameel M. and Dyment, David Alexandre and Herrera, Blanca M. and Orton, Sarah-Michelle and Degenhardt, Alexandra and Pugliatti, Maura and Sadovnick, A. Dessa and Sotgiu, Stefano and Ebers, George C. (2007) The Role of hereditary spastic paraplegia related genes in multiple sclerosis: a study of disease susceptibility and clinical outcome. Journal of Neurology, Vol. 254 (9), p. 1221-1226. eISSN 1432-1459. Article.

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DOI: 10.1007/s00415-006-0505-4

Abstract

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. It has been observed that axonal loss in MS is significant and that irreversible clinical disability relates to such axonal loss. The clinical similarities between Hereditary Spastic Paraplegia (HSP) and progressive MS, along with their analogous profiles of axonal loss in the long tracts, make the genes known to cause HSP biologically relevant candidates for the study of clinical outcome in MS. A cohort of sporadic MS cases and a set of unaffected controls were used to determine the role of HSP genes on MS susceptibility and disease severity. The MS cases were taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date. Genotyping the two sets of MS patients and controls could not provide any evidence to suggest that genes involved in the pathogenesis of HSP (Paraplegin, NIPA1, KIF5A, HSPD1, Atlastin, Spartin, Spastin, PLP1, L1CAM, Maspardin and BSCL2) play a role in susceptibility to, or modifying the course of, MS, although small effects of these genes cannot be ruled out.

Item Type:Article
ID Code:4973
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, genetics
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Springer Berlin / Heidelberg
eISSN:1432-1459
Deposited On:26 Nov 2010 11:08

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