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No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis

Ramagopalan, Sreeram V. and De Luca, Gabriele C. and Morrison, Katie M. and Herrera, Blanca M. and Dyment, David Alexandre and Orton, Sarah-Michelle and Bihoreau, Marie Therese and Degenhardt, Alexandra and Pugliatti, Maura and Sadovnick, A. Dessa and Sotgiu, Stefano and Ebers, George C. (2007) No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis. Journal of Neuroimmunology, Vol. 186 (1-2), p. 156-160. ISSN 0165-5728. Article.

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DOI: 10.1016/j.jneuroim.2007.02.003

Abstract

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. Apolipoprotein E (APOE) is involved in neuronal remodelling and several studies have attempted to examine the effect of APOE on MS disease severity, but its function in modifying the course of MS is controversial. It has been suggested recently that PVRL2, not APOE, is the locus on chromosome 19 which influences clinical outcome of MS. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of APOE and PVRL2 on MS disease severity. The MS cases selected represent the prognostic best 5% (benign MS) and worst 5% (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that APOE and PVRL2 have any outcome modifying activity. We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS.

Item Type:Article
ID Code:4972
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, candidate gene, outcome, APOE, PVRL2, Sardinia
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier
ISSN:0165-5728
Deposited On:26 Nov 2010 11:04

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