Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide

Morale, Maria Concetta and Serra, Pier Andrea and Delogu, Maria Rosaria and Migheli, Rossana and Rocchitta, Gaia Giovanna Maria and Tirolo, Cataldo and Caniglia, Salvo and Testa, Nuccio and L'Episcopo, Francesca and Gennuso, Florinda and Scoto, Giovanna M. and Barden, Nicholas and Miele, Egidio and Desole, Maria Speranza and Marchetti, Bianca Maria (2004) Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide. The FASEB Journal, Vol. 18 (1), p. 164-166. eISSN 1530-6860. Article.

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DOI: 10.1096/fj.03-0501fje

Abstract

Emerging evidence indicates that an inflammatory process is involved in dopaminergic nigrostriatal neuron loss in Parkinson’s disease (PD). We have investigated the effect of lifelong glucocorticoid receptor (GR) deficiency of transgenic (Tg) mice expressing GR antisense RNA from early embryonic life in the vulnerability of the nigrostriatal dopaminergic system to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced experimental PD.

Item Type:	Article
ID Code:	4950
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Parkinson’s disease (PD), glucocorticoid receptor deficiency, nigrostriatal dopaminergic system
Subjects:	Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:	001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:	The Federation of the American Societies for Experimental Biology
eISSN:	1530-6860
Deposited On:	23 Nov 2010 12:46

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