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Safety and tolerability in relapsing-remitting multiple sclerosis patients treated with high-dose subcutaneous interferon-beta by rebiject autoinjection over a 1-year period: The CoSa study

Lugaresi, Alessandra and Durastanti, Valentina and Gasperini, Claudio and Lai, Marina and Pozzilli, Carlo and Orefice, Giuseppe and Sotgiu, Stefano and Pucci, Emilio and Ardito, Bruno and Millefiorini, Enrico (2008) Safety and tolerability in relapsing-remitting multiple sclerosis patients treated with high-dose subcutaneous interferon-beta by rebiject autoinjection over a 1-year period: The CoSa study. Clinical Neuropharmacology, Vol. 31 (3), p. 167-172. eISSN 1537-162X. Article.

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DOI: 10.1097/wnf.0b013e3181571a8e

Abstract

Objectives: Approved multiple sclerosis (MS) treatments include subcutaneous and intramuscular interferon beta (IFN-β) Patient satisfaction during long-term IFN-β treatment is crucial. This study investigated the satisfaction of patients with relapsing-remitting MS treated with IFN-β-1a (Rebif) by the autoinjection system, Rebiject.
Materials and Methods: This prospective observational study recruited subjects with relapsing-remitting MS (n = 76) from 19 neurological centers in Italy who were eligible for subcutaneous IFN-β-1a treatment either as a first immunomodulatory therapy or as a switch from other treatments. Patients received IFN-β-1a 44 μg 3 times weekly via the Rebiject system. A questionnaire on the use of Rebiject and the most common adverse effects related to IFN-β-1a administration was completed monthly under the supervision of trained nurses.
Results: Satisfaction with treatment was reported by 80.2% of patients who received at least 1 dose. Advantages reported for the Rebiject system included its convenience (53% of all patients), ease of use (25%), reduced trauma and pain (11% and 6%, respectively), and reduced local skin reactions (5%). No significant changes from baseline were observed regarding the frequency or severity of local reactions.
Conclusions: During the 1-year observation of this small cohort, most patients considered the Rebiject system to be convenient, with a third of the patients feeling that the system was easier to use than conventional procedures. Rebiject was also associated with less pain and trauma in some patients. Use of Rebiject may facilitate IFN-β-1a administration and may lead to an increase in compliance and adherence, thus increasing the effectiveness of treatment.

Item Type:Article
ID Code:4909
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, interferon beta, patient satisfaction, autoinjection system, rebiject
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Lippincott, Williams & Wilkins
eISSN:1537-162X
Additional Information:Fra gli autori è presente un gruppo di ricerca: The CoSa Study group
Deposited On:23 Nov 2010 12:17

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