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Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by capillary electrophoresis/mass spectrometry

Nieddu, Maria and Boatto, Gianpiero and Pirisi, Maria Antonietta and Dessì, Giuseppina (2010) Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by capillary electrophoresis/mass spectrometry. Rapid Communications in Mass Spectrometry, Vol. 24 (16), p. 2357-2362. eISSN 1097-0231. Article.

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DOI: 10.1002/rcm.4656

Abstract

An analytical procedure for the simultaneous determination in human urine of four thiophenethylamine designer drugs (2C-T series) is reported. The quantitative analysis was performed by capillary electrophoresis with mass spectrometric detection (CE/MS), using 2,5-dimethoxy-4-methylthiophenethylamine-D4 (2C-T-D4) as internal standard. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid-phase extraction (SPE) was introduced in the method as a clean-up step. The method was validated according to international guidelines. The data for accuracy and precision were within required limits. Calibration curves were generated over the range from 10 to 500 ng mL−1 and correlation coefficients always exceeded 0.997. The method was demonstrated to be specific, sensitive, and reliable for the analysis of these derivatives in urine samples.

Item Type:Article
ID Code:4900
Status:Published
Refereed:Yes
Uncontrolled Keywords:Thiophenethylamine drugs, human urine, capillary electrophoresis/mass
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Wiley
eISSN:1097-0231
Deposited On:23 Nov 2010 11:21

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