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Corneal graft rejection after penetrating keratoplasty for keratoconus in Turner's syndrome

Pinna, Antonio <1963- > and Salvo, Marco Michele and Dore, Stefano and Carta, Francesco (2005) Corneal graft rejection after penetrating keratoplasty for keratoconus in Turner's syndrome. European Journal of Ophthalmology, Vol. 15 (2), p. 271-273. eISSN 1724-6016. Article.

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Abstract

Purpose. To report a patient with Turner's syndrome who developed graft rejection after penetrating keratoplasty (PK) for keratoconus and to review the ophthalmic literature on the association between keratoconus and Turner's syndrome. Methods. A woman with bilateral keratoconus and Turner's syndrome (45,XO) was referred for progressive visual loss in the right eye. Best-corrected visual acuity was 20/400 in the right eye. Slit-lamp examination revealed corneal thinning with ectatic protrusion of the central cornea and Vogt's striae in the right eye. The patient underwent PK in the right eye in January 2001. She developed graft rejection in April 2003 and visual acuity dropped to hand motion. After treatment with topical and systemic steroids and systemic cyclosporine A, visual acuity recovered to 20/80 in July 2003. Results. The authors know of only three other reported patients (six eyes) with keratoconus in Turner's syndrome. Five eyes underwent PK with good visual rehabilitation, but one developed immunologic graft rejection 7 years after surgery. On the whole, considering the current report and the other cases described in the literature, graft rejection occurred in 2 out of 6 eyes (33.3%). The graft survival rate was 80% after 2 years and 40% after 7 years. Conclusions. The results suggest that grafts for keratoconus in patients with Turner's syndrome might have an increased risk of immunologic rejection. Corneal grafts in Turner's syndrome need to be monitored closely. Early detection of graft rejection and aggressive treatment with topical and systemic steroids and systemic cyclosporine A can save the graft and restore useful vision.

Item Type:Article
ID Code:4826
Status:Published
Refereed:Yes
Uncontrolled Keywords:Turner's syndrome, keratoconus, penetrating keratoplasty, immunologic graft rejection
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Divisions:001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
Publisher:Wichtig
eISSN:1724-6016
Deposited On:15 Nov 2010 14:31

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