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Ni(II)-Histone H4 interactions: structural modifications

Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella (2010) Ni(II)-Histone H4 interactions: structural modifications. In: 21. Spanish-Italian Congress on Thermodynamics of Metal Complexes ISMEC 2010, 7-11 June 2010, Bilbao, Spain. [S.l.], Universidad del Paìs Vasco. p. 52. Conference or Workshop Item.

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Abstract

It is known that nickel participates to carcinogenic processes through mechanisms interfering with several cellular targets; among them, histone H4 has been recently identified. Histones are nuclear proteins that package and organize DNA into nucleosomes and chromatin, but they are also involved in gene regulation and transcription. By undergoing post-translational modifications, such as acetylation, methylation and phosphorylation, they change chromatin structure helping gene transcription or inhibition. Nickel showed to be in vivo a potent inhibitor of histone H4 acetylation. Acetylation causes important structural modifications in histones: for instance, it increases the α-helix content, thus decreasing the length of the histone tail and affecting the transcription mechanisms.

Item Type:Conference or Workshop Item (Lecture)
ID Code:4821
Status:Published
Uncontrolled Keywords:Histone H4, nickel interactions
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Universidad del Paìs Vasco
Additional Information:Abstract OC16 from Book of Abstracts: ISMEC2010. International Symposium on Metal Complexes ISMEC2010. Bilbao 7th-11th June 2010
Deposited On:15 Nov 2010 11:06

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