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Copper(II) binding to Cap43 protein fragments

Zoroddu, Maria Antonietta and Kowalik-Jankowska, Teresa and Medici, Serenella and Peana , Massimiliano Francesco and Kozlowski, Henryk (2008) Copper(II) binding to Cap43 protein fragments. Dalton Transactions, Vol. 2008 (44), p. 6127-6134. eISSN 1477-9234. Article.

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DOI: 10.1039/b808600a


The C-terminal 20 and 30 amino acid sequences of Cap43 protein were chosen as models to study their interactions with Cu(II) ions. The behaviour of the 20 amino acid Ac–TRSRSH6TSEG–TRSRSH16TSEG and 30 amino acid Ac–TRSRSH6TSEG–TRSRSH16TSEG–TRSRSH26TSEG peptides towards Cu(II) ions at different pH values and different ligand-to-metal molar ratios, was examined. Spectroscopic (EPR, UV-Vis) and potentiometric techniques were performed to understand the details of metal binding to the peptides. The study showed that, starting from pH 4.0, each 10 amino acid fragment T1R2S3R4S5H6T7S8E9G10 was able to independently coordinate a single Cu(II) ion. The coordination mode involved the imidazole nitrogen of histidine H6 residue, and three amidic nitrogens from histidine H6, serine S5, and arginine R4 residues, respectively.

Item Type:Article
ID Code:4809
Uncontrolled Keywords:Copper(II), Cap43 protein, peptides, Cu(II) ions
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Royal Society of Chemistry
Deposited On:12 Nov 2010 10:31

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