Metal-chelating properties of carvedilol: an antihypertensive drug with antioxidant activity

Zoroddu, Maria Antonietta and Medici, Serenella and Peana, Massimiliano Francesco (2009) Metal-chelating properties of carvedilol: an antihypertensive drug with antioxidant activity. Journal of Coordination Chemistry, Vol. 62 (23), p. 3828-3836. ISSN 0095-8972. eISSN 1029-0389. Article.

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DOI: 10.1080/00958970903267280

Abstract

Carvedilol (CarvH) (1-[carbazolyl-(4)-oxyl]-3-[2-methoxyphenoxyethyl)-amino]-2-propanol, an antihypertensive agent with β-blocker function, has been shown to act as an antioxidant. The antioxidative properties can be correlated with metal chelating ability of the drug. Iron(III), zinc(II), and copper(II) complexes of carvedilol were synthesized and characterized with respect to their structural and spectroscopic properties. Metal interaction involves O and N donors from the aliphatic moiety of carvedilol. NMR studies allowed us to obtain the structural information on metal coordination and to suggest that the physiological concentration of carvedilol and free metal ions may be enough for a protective effect by metal chelation.

Item Type:	Article
ID Code:	4806
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Carvedilol, Iron(III), Zinc(II), Cu(II); Chelating, antioxidant drug
Subjects:	Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:	Taylor & Francis
ISSN:	0095-8972
eISSN:	1029-0389
Deposited On:	12 Nov 2010 10:22

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