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Immunohistochemistry and biomolecular investigation for the evidence of JSRV-like retrovirus in human bronchiolo-alveolar carcinomas

Rocca, Stefano and Sanna, Maria Paola and Farigu, Serafina and Pirino, Salvatore and Cossu, Antonio and Palmieri, Giuseppe and Lissia, Amelia and Leoni, Antonio (2005) Immunohistochemistry and biomolecular investigation for the evidence of JSRV-like retrovirus in human bronchiolo-alveolar carcinomas. In: 2. Congresso nazionale A.I.P.Vet.: atti, 20-21 Maggio 2005, Lodi, Italia. Milano, AIPVet. p. 27-30. ISSN 1825-2265. Conference or Workshop Item.

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Abstract

The bronchioloalveolar adenocarcinoma was described in several species (human, bovine, ovine and domestic carnivores). Ovine pulmonary adenocarcinoma (OPA) or pulmonary adenomatosis is a contagious carcinoma of sheep caused by an exogenous type D retrovirus denominated also jaagsiekte sheep retrovirus (JSRV). JSRV is responsible of the neoplastic transformation of type II pneumocytes and Clara cells. The human bronchioloalveolar adenocarcinoma (BAC) have histo-morphological features much similar to OPA. We report the study about ten BAC cases and one negative human control (lung). DNA extraction, PCR, sequencing of amplified product, immunohistochemistry and insitu hybridization were performed on all paraffin-embedded samples. Our results demonstrated the presence of JSRVlike sequences in all cases of human bronchiolo-alveolar carcinoma.

Item Type:Conference or Workshop Item (Contribute)
ID Code:478
Status:Published
Uncontrolled Keywords:Bronchioloalveolar adenocarcinoma, sheep pulmonary adenomatosis, in-situ hybridization, immunohistochemistry
Subjects:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
001 Università di Sassari > 03 Istituti > Anatomia patologica
Publisher:AIPVet
ISSN:1825-2265
Deposited On:18 Aug 2009 10:02

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