Antimanic and mood-stabilizing effect of memantine as an augmenting agent in treatment-resistant bipolar disorder

Koukopoulos, Athanasios and Reginaldi, Daniela and Serra, Giulia and Koukopoulos, Alexia and Sani, Gabriele and Serra, Gino (2010) Antimanic and mood-stabilizing effect of memantine as an augmenting agent in treatment-resistant bipolar disorder. Bipolar Disorders, Vol. 12 (3), p. 348-349. ISSN 1399-5618. Article.

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DOI: 10.1111/j.1399-5618.2010.00803.x

Abstract

Memantine is a selective, uncompetitive N-methyl- D-aspartate (NMDA) receptor antagonist, currently used in the treatment of Alzheimers disease. Many clinical trials have demonstrated its tolerability and safety. We have suggested that antidepressants induce mania and rapid cycling by sensitizing dopamine D2 receptors and demonstrated that the sensitization induced by antidepressants requires the stimulation of NMDA receptors. It is tempting to suggest that the phenomenon of sensitization could underlie the spontaneous development and the course of mania as well.

Item Type:	Article
ID Code:	4768
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Bipolar disorders, memantine treatment
Subjects:	Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:	Blackwell / Wiley
ISSN:	1399-5618
Copyright Holders:	© 2010 The Authors, Journal compilation © 2010 Blackwell Munksgaard
Deposited On:	04 Nov 2010 13:56

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