titoli, abstracts, parole chiave >>>
In Vitro evaluation of the effectiveness of the macrolide rokitamycin and chlorpromazine against Acanthamoeba castellanii

Mattana, Antonella and Biancu, Giampiero and Alberti, Luisa and Accardo, Andrea and Delogu, Giuseppe and Fiori, Pier Luigi and Cappuccinelli, Pietro Antonio (2004) In Vitro evaluation of the effectiveness of the macrolide rokitamycin and chlorpromazine against Acanthamoeba castellanii. Antimicrobial Agents and Chemotherapy, Vol. 48 (12), p. 4520-4527. ISSN 0066-4804. eISSN 1098-6596. Article.

Full text not available from this repository.

DOI: 10.1128/AAC.48.12.4520-4527.2004

Alternative URLs:

Abstract

The present study demonstrates the in vitro effectiveness of the macrolide rokitamycin and the phenothiazine compound chlorpromazine against Acanthamoeba castellanii. Growth curve evaluations revealed that both drugs inhibit trophozoite growth in dose- and time-dependent ways. The effects of both drugs when they were used at the MICs at which 100% of isolates are inhibited were amoebistatic, but at higher doses they were amoebicidal as well as cysticidal. Experiments showed that when rokitamycin was associated with chlorpromazine or amphotericin B, rokitamycin enhanced their activities. Furthermore, low doses of rokitamycin and chlorpromazine, alone or in combination, blocked the cytopathic effect of A. castellanii against WKD cells derived from the human cornea. These results may have important significance in the development of new anti-Acanthamoeba compounds.

Item Type:Article
ID Code:4764
Status:Published
Refereed:Yes
Uncontrolled Keywords:Antiamoebic drugs, Acanthamoeba, rokitamycin, chlorpromazine
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:American Society for Microbiology
ISSN:0066-4804
eISSN:1098-6596
Deposited On:05 Nov 2010 10:05

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page