Mattana, Antonella and Serra, Caterina and Delogu, Giuseppe and Mariotti, Elisabetta and Fiori, Pier Luigi and Cappuccinelli, Pietro Antonio (2006) Acanthamoeba castellaniipromotion of in vitro survival and transmission of coxsackie B3 viruses. Eukaryotic Cell, Vol. 5 (4), p. 665-671. eISSN 1535-9786. Article.
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This work was undertaken to determine whether Acanthamoeba could play a role in the survival and transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and their transmission to human hosts.
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