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Acanthamoeba castellanii promotion of in vitro survival and transmission of coxsackie B3 viruses

Mattana, Antonella and Serra, Caterina and Delogu, Giuseppe and Mariotti, Elisabetta and Fiori, Pier Luigi and Cappuccinelli, Pietro Antonio (2006) Acanthamoeba castellaniipromotion of in vitro survival and transmission of coxsackie B3 viruses. Eukaryotic Cell, Vol. 5 (4), p. 665-671. eISSN 1535-9786. Article.

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DOI: 10.1128/EC.5.4.665-671.2006

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Abstract

This work was undertaken to determine whether Acanthamoeba could play a role in the survival and transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and their transmission to human hosts.

Item Type:Article
ID Code:4762
Status:Published
Refereed:Yes
Uncontrolled Keywords:Acanthamoeba, Coxsackieviruses, human macrophages
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:American Society for Microbiology
eISSN:1535-9786
Deposited On:05 Nov 2010 10:01

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