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I Carcinomi in situ della mammella: inquadramento clinico ed attualità

Attene, Federico and Scognamillo, Fabrizio and Trignano, Emilio and Meloni, Giovanni Battista and Rubino, Corrado and Trignano, Mario (2006) I Carcinomi in situ della mammella: inquadramento clinico ed attualità. Annali italiani di chirurgia, Vol. 77 (1), p. 3-12. ISSN 0003-469X. Article.

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INTRODUCTION: Lobular and ductal carcinomas in situ of the breast (LCIS and DCIS) origin from the ductal-lobular unit of mammary gland, but they are characterized for different morphologic patterns and evolution. In 1980 they represent 1.4% of diagnosis in breast biopsy, less of 5% of carcinomas of the breast. Actually in 7.5% of breast biopsy an in situ carcinoma is recognized (approximating 40% of breast cancers). Our purpose is to evaluate the different available strategies in the clinic management of DCIS and LCIS and, in case of surgical treatment, which reconstructive approach obtains satisfactory breast conformation.
MATERIALS AND METHODS: The study enclose 125 patients: 40 of them presented LCIS (32%) and 85 DCIS (68%). In 40 patients (32%) underposed to mastectomy was performed a reconstruction in cooperation with aesthetic surgeons. 35 of 40 women with LCIS are included in a follow-up programme, 5 of them had a bilateral mastectomy and reconstruction.
RESULTS: No recurrences were observed in patients affected by LCIS. Six patients underposed to wide excision for DCIS developed local recurrence, treated by mastectomy. No recurrences were observed in patients treated initially with mastectomy. Some complications correlated to reconstruction were detected.
CONCLUSIONS: One of most controversial sights in breast pathology is the understanding of biological meaning of CLIS: in facts CDIS can be considered a pre-invasive cancer, CLIS is reasonably considerable only a risk indicator for developing breast cancer but it isn’t a pre-neoplastic lesion. Very important is the reconstruction of the breast to improve the quality life of patients.

Item Type:Article
ID Code:4750
Uncontrolled Keywords:Carcinoma in situ, mastectomy, segmental mastectomy, tumor recurrence
Subjects:Area 06 - Scienze mediche > MED/19 Chirurgia plastica
Area 06 - Scienze mediche > MED/36 Diagnostica per immagini e radioterapia
Area 06 - Scienze mediche > MED/18 Chirurgia generale
Divisions:001 Università di Sassari > 03 Istituti > Scienze radiologiche
001 Università di Sassari > 03 Istituti > Patologia chirurgica
001 Università di Sassari > 03 Istituti > Dermatologia
Publisher:Edizioni Luigi Pozzi
Deposited On:03 Nov 2010 12:45

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