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Bilateral ovarian malignant mixed Müllerian tumor in a dog

Antuofermo, Elisabetta and Cocco, Raffaella and Borzacchiello, Giuseppe and Burrai, Giovanni and Meloni, Floriana and Bonelli, Piero and Pirino, Salvatore and Cossu Rocca, Paolo Alessandro and Bosincu, Luisanna (2009) Bilateral ovarian malignant mixed Müllerian tumor in a dog. Veterinary Pathology, Vol. 46 (3), p. 453-456. eISSN 1544-2217. Article.

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DOI: 10.1354/vp.08-VP-0151-A-BC

Abstract

Malignant mixed Müllerian tumor (MMMT) is a rare neoplasm of the female genital tract. We report a case of bilateral ovarian MMMT in a 10-year-old female dog. Ovaries were only moderately enlarged with a papillary surface and firm nodules. Multiple metastases were observed in the abdominal cavity and pulmonary parenchyma. Histologically, both ovaries had intermingled carcinomatous and sarcomatous components with cartilage and bone. Metastatic lesions were not mixed. The peritoneal metastases were carcinomatous; pulmonary metastases were sarcomatous. Carcinomatous elements of the MMMT were immunohistochemically positive for cytokeratin (CK) AE1/AE3, CK7, and vimentin and estrogen receptors. Conversely, the sarcomatous cells were positive for vimentin, but negative for CKs. Chondrocytes also expressed S-100 protein. On the basis of similarities to human ovarian MMMT, the diagnosis was heterologous malignant mixed Müllerian tumor of the ovary.

Item Type:Article
ID Code:4720
Status:Published
Refereed:Yes
Uncontrolled Keywords:Carcinosarcoma, dogs, immunohistochemistry, mixed Müllerian tumor, ovary
Subjects:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
001 Università di Sassari > 03 Istituti > Anatomia patologica
Publisher:Sage
eISSN:1544-2217
Copyright Holders:© American College of Veterinary Pathologists, European College of Veterinary Pathologists, & the Japanese College of Veterinary Pathologists
Deposited On:22 Oct 2010 11:12

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