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Genetic immunization with the immunodominant antigen P48 of Mycoplasma agalactiae stimulates a mixed adaptive immune response in BALBc mice

Chessa, Bernardo and Pittau, Marco and Puricelli, Maria and Zobba, Rosanna and Coradduzza, Elisabetta and Dall'Ara, Paola and Rosati, Sergio and Poli, Giorgio and Alberti, Alberto (2009) Genetic immunization with the immunodominant antigen P48 of Mycoplasma agalactiae stimulates a mixed adaptive immune response in BALBc mice. Research in Veterinary Science, Vol. 86 (3), p. 414-420. ISSN 0034-5288. Article.

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DOI: 10.1016/j.rvsc.2008.09.010

Abstract

A DNA vaccine against contagious agalactia was developed for the first time, encoding the P48 of Mycoplasma agalactiae. Specific immune responses elicited in BALB/c mice were evaluated. Both total IgG and IgG1 were detected in mice vaccinated with pVAX1/P48. Proliferation of mononuclear cells of the spleen, levels of gamma interferon, interleukin-12, and interleukin-2 mRNAs were enhanced in immunized animals. Results indicate that pVAX1/P48 vaccination induced both Th1 and Th2 immune responses. Nucleic acid immunization could be a new strategy against M. agalactiae infections and may be potentially used to develop vaccines for other Mycoplasma diseases.

Item Type:Article
ID Code:4719
Status:Published
Refereed:Yes
Uncontrolled Keywords:Genetic immunization, DNA vaccines, Mycoplasma agalactiae, artificial active immunity
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/05 Malattie infettive degli animali domestici
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
Publisher:Elsevier
ISSN:0034-5288
Deposited On:22 Oct 2010 10:56

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