Montisci, Roberta and Ruscazio, Massimo and Vacca, Alessandra and Garau, Pietro and Passiu, Giuseppe and Mathieu, Alessandro and Iliceto, Sabino and Meloni, Luigi (2004) Effect of acute administration of L-propionylcarnitine on coronary flow velocity reserve in patients with systemic sclerosis. Journal of the American College of Cardiology, Vol. 43 (5, Suppl. 1), p. A231. ISSN 0735-1097. Article.
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Background. Cardiac involvement in systemic sclerosis ( SSc) is controversial but the
primary disorder of microvasculature with diffuse arteriolar and capillary lesions could
precede any fibrosis, thus causing ischemic dysfunction. Previous studies of coronary
flow velocity reserve (CFVR) have demonstrated that CFVR is impaired in patients with
SSc. L-Propionylcarnitine( L-Pc) is a metabolic substance that exerts a beneficial effect
on both microcirculation and myocite function. We tested the hypothesis that CFVR can
be early impaired in patients with SSc without cardiac involvement and whether CFVR
could improve after intravenous administration of L-Pc.
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