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Absence of epicardial coronary stenosis in patients with systemic sclerosis with severe impairment of coronary flow reserve

Vacca, Alessandra and Siotto, Paolo and Cauli, Alberto and Montisci, Roberta and Garau, Pietro and Ibba, Valentina and Mameli, Antonella and Passiu, Giuseppe and Iliceto, Sabino and Mathieu, Alessandro (2006) Absence of epicardial coronary stenosis in patients with systemic sclerosis with severe impairment of coronary flow reserve. Annals of the Rheumatic Diseases, Vol. 65 (2), p. 274-275. eISSN 1468-2060. Article.

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DOI: 10.1136/ard.2005.040154

Abstract

Systemic sclerosis (SSc) is known to be characterised by a diffuse microvascular pathological process leading to cutaneous and visceral changes and to related clinical manifestations.
Both necropsy studies and in vivo investigations have shown that in a number of patients with SSc there is evidence of a coronary microvascular disease, while coronary artery disease does not exceed that seen in a control group. In particular, myocardial perfusion defects on thallium-201 scintigraphy usually occur in the absence of angiographic evidence of coronary stenosis.
Recently, we used a new and non-invasive method of contrast enhanced, transthoracic, second harmonic echo Doppler in patients with SSc to evaluate the coronary flow reserve (CFR), a functional variable measuring the ability of the coronary microvasculature to adapt its lumen to a vasodilating stimulus.

Item Type:Article
ID Code:4685
Status:Published
Refereed:Yes
Uncontrolled Keywords:Spiral computed-tomography, scleroderma, angiography
Subjects:Area 06 - Scienze mediche > MED/16 Reumatologia
Divisions:001 Università di Sassari > 03 Istituti > Patologia speciale medica e metodologia clinica
Publisher:BMJ Publishing Group
eISSN:1468-2060
Copyright Holders: © 2007 BMJ Publishing Group Ltd & European League Against Rheumatism
Deposited On:14 Oct 2010 13:36

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