Cauli, Alberto and Vacca, Alessandra and Mameli, Antonella and Passiu, Giuseppe and Fiorillo, Maria Teresa and Sorrentino, Rosa and Mathieu, Alessandro (2007) A Sardinian patient with ankylosing spondylitis and HLA–B*2709 co-occurring with HLA–B*1403. Arthritis & Rheumatism, Vol. 56 (8), p. 2807-2809. eISSN 1529-0131. Article.
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The HLA–B*2709 allele, originally identified among the Italian population, has not been found to be associated with ankylosing spondylitis (AS) in the populations of Sardinia or continental Italy. It has been reported to be present in a few patients with undifferentiated seronegative arthritis without axial involvement and in a patient with psoriatic arthritis with only peripheral arthritis. Structural and functional differences, which might account for differential susceptibility to AS (and sacroiliitis), have been found between the B*2705 subtype, which is associated with AS, and B*2709, which so far does not seem to be associated. The B*2709 subtype may have a neutral role in susceptibility to AS, like any other non–AS-related allele of the B locus, and some sporadic cases of B*2709 positivity among AS patients would therefore be expected to occur by chance and should be regarded as B27-negative AS. To date, however, none have been reported. Furthermore, when considering susceptibility to AS, one must take into account the fact that several genes besides B27 have been implicated. Herein we report on a patient with AS who was positive for HLA–B*2709.
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