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Effect of rituximab on clinical and laboratory features of antiphospholipid syndrome: a case report and a review of literature

Erre, Gian Luca and Pardini, Simonetta and Faedda, Rossana and Passiu, Giuseppe (2008) Effect of rituximab on clinical and laboratory features of antiphospholipid syndrome: a case report and a review of literature. Lupus, Vol. 17 (1), p. 50-55. eISSN 1477-0962. Article.

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DOI: 10.1177/0961203307085251

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by a hypercoagulable state related to persistently elevated levels of antiphospholipid antibodies (aPL). Current treatment for APS is only partially effective and new therapies are strongly needed.
We report on a case of a 50 years old man with APS who suffered from recurrent thromboembolic episodes despite conventional anticoagulant treatment. Eight years after the first thrombotic manifestation he was diagnosed with a large B cell non-Hodgkin lymphoma. Treatment with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) plus rituximab was started with partial clinical remission of lymphoma and normalization of aPL levels with a three years follow-up period free of thrombotic episodes.
A review of the literature revealed that only 12 case reports on the use of rituximab in patients with primary, secondary and catastrophic APS have been published. Current knowledge clearly suggests the need for clinical trials to evaluate the effect of rituximab in the treatment of resistant APS.

Item Type:Article
ID Code:4674
Status:Published
Refereed:Yes
Uncontrolled Keywords:Antiphospholipid syndrome (APS), antiphospholipid antibodies, rituximab, lupus anticoagulant, lymphoma
Subjects:Area 06 - Scienze mediche > MED/16 Reumatologia
Area 06 - Scienze mediche > MED/14 Nefrologia
Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
001 Università di Sassari > 03 Istituti > Patologia speciale medica e metodologia clinica
Publisher:SAGE Publications
eISSN:1477-0962
Deposited On:12 Oct 2010 19:18

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