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Association of MICA alleles with psoriatic arthritis and its clinical forms: a multicenter Italian study

Mameli, Antonella and Cauli, Alberto and Taccari, Egisto and Scarpa, Raffaele and Punzi, Leonardo and Lapadula, Giovanni and Peluso, Rosario and Ramonda, Roberta and Spadaro, Aldo and Iannone, Florenzo and Fanni, V. and Vacca, Alessandra and Passiu, Giuseppe and Fiorillo, Maria Teresa and Carcassi, Carlo and Sorrentino, Rosa and Mathieu, Alessandro (2008) Association of MICA alleles with psoriatic arthritis and its clinical forms: a multicenter Italian study. Clinical and Experimental Rheumatology, Vol. 26 (4), p. 649-652. ISSN 1593-098X. Article.

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Abstract

OBJECTIVES: Analysis of the association between psoriatic arthritis (PsA) clinical forms and MICA gene transmembrane polymorphisms.
METHODS: Patients were classified as having peripheral asymmetric oligoarthritis (AO), peripheral symmetric poly-arthritis (PA) and spondylitis (SP), or disease combinations (PA/SP, OA/SP). Two hundred and twenty-six patients with PsA were typed for MICA exon 5 microsatellite (TM) by heteroduplex analysis and compared with 225 normal controls.
RESULTS: MICA-TM microsatellite typing revealed that, among the different clinical forms of PsA, only the combined PA/SP subset shows a significant positive association with MICA-A9 and a lower frequency of MICA-A4, A5 genotype in PsA patients with a decrease, only in the PA/SP cohort, of all MICA-A5 combinations except MICA-A5, -A9.
CONCLUSIONS: These results suggest a role for genes within the HLA region in the pathogenesis of PsA, and reinforce the idea that the different forms of PsA may have heterogeneous genetic basis.

Item Type:Article
ID Code:4673
Status:Published
Refereed:Yes
Uncontrolled Keywords:MICA alleles, psoriatic arthritis (PsA), Italy
Subjects:Area 06 - Scienze mediche > MED/16 Reumatologia
Divisions:001 Università di Sassari > 03 Istituti > Patologia speciale medica e metodologia clinica
Publisher:Clinical and Experimental Rheumatology
ISSN:1593-098X
Deposited On:12 Oct 2010 18:56

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