Arru, Giannina and Mameli, Giuseppe and Asone, Vito and Serra, Caterina and Huang, Yu-Min and Link, Hans and Fainardi, Enrico and Castellazzi, Massimiliano and Granieri, Enrico and Fernandez, Miriam and Villoslada, Paolo and Fois, Maria Laura and Sanna, Alessandra and Rosati, Giulio and Dolei, Antonina and Sotgiu, Stefano (2007) Multiple sclerosis and HERV-W/MSRV: a multicentric study. International Journal of Biomedical Science, Vol. 3 (4), p. 292-297. ISSN 1555-2810. Article.
We designed a large multicentric study to analyse the presence of MSR V particles in blood and CS F of a large cohort of patients and controls from different European areas. 149 MS patients and 153 neurological and healthy controls were selected from Sardinia, Spain, Northern-Italy and Sweden. To avoid biological and inter-assay variability MSR V was detected within a single laboratory through nested and real-time PCR assays specific for pol and env genes. MSR V detection in blood and CS F of MS patients and controls in populations of different ethnicity gave significant differences (p<0.05 compared to neurological controls and p<0.001 compared to healthy controls). The presence and viral load of MSRV are significantly associated with MS as compared to neurological and healthy controls in all ethnic groups.
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