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Reactions of alkylation of biologically interesting triazolo[4,5-g]quinolines and triazolo[4,5-g]quinoline-1-oxides with electrophilic reagents

Carta, Antonio and Sias, Angela and Piras, Sandra and Paglietti, Giuseppe (2008) Reactions of alkylation of biologically interesting triazolo[4,5-g]quinolines and triazolo[4,5-g]quinoline-1-oxides with electrophilic reagents. Heterocycles, Vol. 75 (10), p. 2493-2505. ISSN 0385-5414. Article.

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DOI: 10.3987/COM-08-11415

Abstract

With the aim to improve the biological activities discovered for compounds containing the triazolo[4,5-g]quinoline nucleus, we describe the chemical behaviour of 4-chlorotriazolo[4,5-g]quinolines (1a,b) and some its triazolo-N1-oxide derivatives (1c-e and II) with electrophilic reagents in order to optimize the synthetic pathways for obtaining both mixtures of N1,2,3-alkyl isomers and selectively N1-O-alkyl derivatives.

Item Type:Article
ID Code:4534
Status:Published
Refereed:Yes
Uncontrolled Keywords:Triazolo[4,5-g]quinoline, Triazolo[4,5-g]quinoline-1-oxides, electrophilic reagents
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier
ISSN:0385-5414
Deposited On:13 Sep 2010 10:02

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