Corona, Paola and Piras, Sandra and Palomba, Michele Francesco Luigi and Carta, Antonio (2008) Synthesis of linear azolo and pyrido quinolines from quinoline derivatives. Mini - Reviews in Organic Chemistry, Vol. 5 (4), p. 295-302. ISSN 1570-193X. Article.
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Angular N-tricyclic systems as triazolo[ 4,5-f]quinolines, triazolo[ 4,5-h] quinolines, imidazo[ 4,5-f]quinolines, imidazo[ 4,5-h]quinolines were in the past obtained by connection of either f or h sides of the quinoline ring and both the adjacent carbon atoms of five-membered rings containing nitrogen atoms. Several attempts at obtaining the corresponding linear N-tricycles were made in the last century, but only the angular derivatives were obtained. Since 2000 a new simple pathway, involving suitable quinoline derivatives, which afforded the linear azolo and pyrido quinolines (imidazo[4,5-g]quinolines, triazolo[ 4,5-g]quinolines and pyrido[2,3-g]quinoxalines) has been developed. Several linear N-tricyclic derivatives have shown some interesting pharmaceutical activity.
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