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Synthesis of linear azolo and pyrido quinolines from quinoline derivatives

Corona, Paola and Piras, Sandra and Palomba, Michele Francesco Luigi and Carta, Antonio (2008) Synthesis of linear azolo and pyrido quinolines from quinoline derivatives. Mini - Reviews in Organic Chemistry, Vol. 5 (4), p. 295-302. ISSN 1570-193X. Article.

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Abstract

Angular N-tricyclic systems as triazolo[ 4,5-f]quinolines, triazolo[ 4,5-h] quinolines, imidazo[ 4,5-f]quinolines, imidazo[ 4,5-h]quinolines were in the past obtained by connection of either f or h sides of the quinoline ring and both the adjacent carbon atoms of five-membered rings containing nitrogen atoms. Several attempts at obtaining the corresponding linear N-tricycles were made in the last century, but only the angular derivatives were obtained. Since 2000 a new simple pathway, involving suitable quinoline derivatives, which afforded the linear azolo and pyrido quinolines (imidazo[4,5-g]quinolines, triazolo[ 4,5-g]quinolines and pyrido[2,3-g]quinoxalines) has been developed. Several linear N-tricyclic derivatives have shown some interesting pharmaceutical activity.

Item Type:Article
ID Code:4530
Status:Published
Refereed:Yes
Uncontrolled Keywords:Imidazo[4,5-g]quinolines, triazolo[4,5-g]quinolines, pyrido[2,3-g]quinoxalines, aminoquinolines, antitubercular activity, antifungal activity, anticancer activity, antiviral activity
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Bentham Science Publishers
ISSN:1570-193X
Deposited On:08 Sep 2010 14:08

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