Auzzas, Luciana and Palomba, Michele Francesco Luigi and Boatto, Gianpiero and Manconi, Paola Maria and Pau, Amedeo and Becciu, A. and Cerri, Riccardo and Tullio, Vivian and Roana, J. and Carlone, Nicola A. (2000) Antidermatophytic action of new 1-naphthylmethyl and benzo[b]thiophen-7-ylmethyl hydrazones related to inhibitors of squalene epoxidase. Die Pharmazie, Vol. 55 (7), p. 483-489. ISSN 0031-7144. Article.
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Two series of hydrazonic compounds related to main classes of inhibitors of fungal squalene epoxidase (SE) were designed and prepared on the hypothesis of a pharmacophoric model. The antifungal activity of the new compounds was evaluated in vitro against dermatophytes, moulds and yeasts. Antidermatophytic activity resulted for several hydrazones, particularly for those containing a tett-butylacetylenic group, supporting the hypothesis that the introduction of a hydrazonic function in the model could retain the antimycotic activity.
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