Antidermatophytic action of new 1-naphthylmethyl and benzo[b]thiophen-7-ylmethyl hydrazones related to inhibitors of squalene epoxidase

Auzzas, Luciana and Palomba, Michele Francesco Luigi and Boatto, Gianpiero and Manconi, Paola Maria and Pau, Amedeo and Becciu, A. and Cerri, Riccardo and Tullio, Vivian and Roana, J. and Carlone, Nicola A. (2000) Antidermatophytic action of new 1-naphthylmethyl and benzo[b]thiophen-7-ylmethyl hydrazones related to inhibitors of squalene epoxidase. Die Pharmazie, Vol. 55 (7), p. 483-489. ISSN 0031-7144. Article.

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Abstract

Two series of hydrazonic compounds related to main classes of inhibitors of fungal squalene epoxidase (SE) were designed and prepared on the hypothesis of a pharmacophoric model. The antifungal activity of the new compounds was evaluated in vitro against dermatophytes, moulds and yeasts. Antidermatophytic activity resulted for several hydrazones, particularly for those containing a tett-butylacetylenic group, supporting the hypothesis that the introduction of a hydrazonic function in the model could retain the antimycotic activity.

Item Type:	Article
ID Code:	4528
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Ergosterol biosynthesis, allylamine antimycotics, antifungal activity, derivatives, agents
Subjects:	Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:	Govi-Verlag
ISSN:	0031-7144
Deposited On:	08 Sep 2010 14:08

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