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Quinoline tricyclic derivatives. Design, synthesis and preliminary in vitro and in silico antiviral activity against flaviridae family of three new classes of virus encoded RNA- dependent polymerase(RdRp)

Carta, Antonio and Vitale, Gabriella and Piras, Sandra and Corona, Paola and Paglietti, Giuseppe and Pricl, Sabrina and Fermeglia, Maurizio and La Colla, Paolo and Giliberti, Gabriele and Collu, David and Loddo, Roberta (2008) Quinoline tricyclic derivatives. Design, synthesis and preliminary in vitro and in silico antiviral activity against flaviridae family of three new classes of virus encoded RNA- dependent polymerase(RdRp). In: 19th National Meeting on Medicinal Chemistry, 14-18 September, 2008, Verona, Italy. P091. Conference or Workshop Item.

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Abstract

As part of our antiviral research program, we have recently synthesized and tested in vitro several series of new angular and linear heterocyclic systems against representatives of ssRNA+ viruses [Bovine Viral Diarrhea Virus (BVDV), Yellow Fever Virus (YFV), Coxsackie B2 (CVB-2), Polio [Sb-1] and Human Immunodeficiency Virus (HIV-1)], ssRNA viruses [Respiratory Syncytial Virus (RSV) and Vesicular Stomatitis Virus (VSV)], dsRNA viruses [Reovirus (Reo-1)], and of DNA viruses [Vaccinia Virus (VV)] [1,2].

Item Type:Conference or Workshop Item (Poster)
ID Code:4517
Status:Published
Uncontrolled Keywords:Triazolo[4,5-g]quinolines, antiviral research, Yellow Fever Virus, DNA viruses
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Deposited On:08 Sep 2010 14:05

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