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Isolation, characterization and pharmacological activity of Magydaris pastinacea (Lam.) Paol. glucosides

Cerri, Riccardo and Pintore, Giorgio Antonio Mario and Dessì, Giuseppina and Asproni, Battistina and Piseddu, Gavino and Sini, Silvia (1995) Isolation, characterization and pharmacological activity of Magydaris pastinacea (Lam.) Paol. glucosides. Il Farmaco, Vol. 50 (12), p. 841-848. ISSN 0014-827X. Article.

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Abstract

The glycoside fraction of fresh rhizomes from Magydaris pastinacea (Lam.) Paol. was separated from the alcoholic extract using the method of Kobayashi et al. The fraction was found to have six main constituents, the most abundant of which had previously been isolated and identified as 7-O-β-D-glucopyranosyl-8-(2',3'-dihydroxy-3-methyl-butylcoumarin). The present paper describes the separation and characterization of the other constituents, all with coumarin or furancoumarin structures. Pharmacological experiments to test these compounds as platelet antiaggregants are also reported.

Item Type:Article
ID Code:4499
Status:Published
Refereed:Yes
Uncontrolled Keywords:Isolation, plant origin, rhizome, medicinal plant, umbelliferae, pharmacognosy, coumarine derivatives, oxygen heterocycle, bicyclic compound, tricyclic compound, aromatic compound, lactone, phenols, alcohol, glycoside, aldose, structural analysis, biological activity, antiplatelet agent, in vitro, human, anticoagulant, dicotyledones, angiospermae, spermatophyta
Subjects:Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Società chimica italiana
ISSN:0014-827X
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:06 Sep 2010 19:25

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