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Monitoring of benzylpenicillin in ovine milk by HPLC

Boatto, Gianpiero and Cerri, Riccardo and Pau, Amedeo and Palomba, Michele Francesco Luigi and Pintore, Giorgio Antonio Mario and Denti, Maria Giovanna (1998) Monitoring of benzylpenicillin in ovine milk by HPLC. Journal of Pharmaceutical and Biomedical Analysis, Vol. 17 (4-5), p. 733-738. eISSN 1873-264X. Article.

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DOI: 10.1016/S0731-7085(97)00245-8

Abstract

A method for ‘in vivo’ determination of the oxytetracyclin residues in ovine milk at low levels is described. Two groups of Sardinian breed sheep were treated with a dose of oxytetracycline by intramammary infusion and intramuscular administration, respectively. Oxytetracycline residues in extracts obtained from a preliminary cleanup procedure, were detected by an isocratic high-performance liquid chromatography (HPLC) method. Linear calibration plots were obtained over a large concentration range of 1 mg ml−1–10 ng ml−1, with correlation coefficients higher than 0.996. Recoveries between 85.8 and 98.9% were obtained. Limit of detection (LOD) and limit of determination (LOQ) were 5.2 and 17.5 ng ml−1, respectively. This method would be useful for routine monitoring of oxytetracycline residues in ovine dairy milk.

Item Type:Article
ID Code:4497
Status:Published
Refereed:Yes
Uncontrolled Keywords:Benzylpenicillin, in vivo monitoring, trace amounts, reversed-phase liquid chromatography, milk
Subjects:Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier
eISSN:1873-264X
Publisher Policy:© 1998 Elsevier Science B.V.
Deposited On:06 Sep 2010 19:24

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