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Asymptomatic cardiac lymphoma in a hepatitis C virus-positive thalassemic patient

Ricchi, Alessandro and Carta, Antonio and Pinna, Gian Marco and Cirio, Emiliano M. and Foddanu, Marco and Terrosu, Pier Franco and Pardini, Simonetta and Fozza, Claudio and Longinotti, Maurizio Roberto (2004) Asymptomatic cardiac lymphoma in a hepatitis C virus-positive thalassemic patient. Italian Heart Journal, Vol. 5 (4), p. 302-204. ISSN 1129-471X. Article.

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Primary cardiac non-Hodgkin lymphomas are fast-growing intracavitary and/or intramyocardial nodular masses, while secondary lymphomas most commonly infiltrate the cardiac tissue. By any definition, cardiac non-Hodgkin lymphomas usually manifest through arrhythmias, refractory heart failure, pericardial effusion, and embolic stroke. We here describe a case of a cardiac non-Hodgkin lymphoma in which the following, previously undescribed features manifest simultaneously. It occorre in a polytransfused hepatitis C virus-positive splenectomized thalassemic patient; it rapidly grew, giving rise to an enormous right atrial mass and, this notwithstanding, it was completely asymptomatic. This cardiac lymphoma was discovered during staging for a CD20+ large B-cell lymphoma of the tonsils. In particular, transesophageal echocardiography, showing that this prolapsing mass had a wide base on the atrial wall, led us to strongly suspect the lymphomatous origin of the mass itself. Notwithstanding anti-CD20 antibody therapy, urgent surgery was unavoidable and histology revealed that the mass consisted of lymphoma proliferation infiltrating even the right atrial wall and the pericardium. During the postoperative course the patient presented with a massive, fatal hemopericardium consequent to intravascular disseminated coagulation. This very unusual case, occurring in a hepatitis C virus-positive thalassemic patient, suggests that a case control study on the incidence of non-Hodgkin lymphoma in such patients may be interesting.

Item Type:Article
ID Code:4492
Uncontrolled Keywords:Cardiac lymphoma, hepatitis C virus, thalassemia
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Deposited On:06 Sep 2010 19:05

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