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Factors for graft-versus-host disease after donor lymphocyte infusions with an escalating dose regimen: lack of association with cell dose

Fozza, Claudio and Szydlo, Richard M. and Abdel-Rehim, Marwa M. and Nadal, Elisabet and Goldman, John M. and Apperley, Jane F. and Dazzi, Francesco (2007) Factors for graft-versus-host disease after donor lymphocyte infusions with an escalating dose regimen: lack of association with cell dose. British Journal of Haematology, Vol. 136 (6), p. 833-836. eISSN 1365-2141. Article.

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DOI: 10.1111/j.1365-2141.2007.06501.x

Abstract

We investigated the risk factors for graft-versus-host disease (GVHD) in 82 patients treated with donor lymphocyte infusions (DLI) using an escalating dose regimen for chronic myeloid leukaemia in relapse following conventional allografting. Two factors emerged as predictors of both acute and chronic GVHD: the infusion of male recipients with lymphocytes from a female donor and the interval between transplant and last DLI, but only the first remained significant at multivariate analysis. Surprisingly, lymphocyte dose did not influence the incidence of GVHD. Our results suggest that DLI can be given in large cell doses without increasing the risk of GVHD.

Item Type:Article
ID Code:4488
Status:Published
Refereed:Yes
Uncontrolled Keywords:Allogeneic stem cell transplantation, chronic myeloid leukaemia, donor lymphocyte infusions, graft-versus-host disease
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
Publisher:Blackwell / Wiley
eISSN:1365-2141
Copyright Holders:© 2007 The Authors, Journal Compilation © 2007 Blackwell Publishing
Deposited On:07 Sep 2010 16:10

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