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Synthesis and in vitro antitumor activity of new quinoxaline derivatives

Corona, Paola and Carta, Antonio and Loriga, Mario and Vitale, Gabriella and Paglietti, Giuseppe (2009) Synthesis and in vitro antitumor activity of new quinoxaline derivatives. European Journal of Medicinal Chemistry, Vol. 44 (4), p. 1579-1591. ISSN 0223-5234. Article.

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DOI: 10.1016/j.ejmech.2008.07.025


A series of novel 5,7-diamino-3-phenyl-2-benzylamino, 2-phenoxy, and 2-thiophenyl substituted quinoxalines has been designed, synthesized and evaluated for their in vitro antitumor activity towards cell lines of nine different types of human cancers. Some of these compounds exhibited inhibitory effects on the growth of a wide range of cancer cell lines generally at 10−6 M, in some cases at 10-7 M and 10−8 M concentrations. Within this series the benzylamino quinoxaline derivatives 1b-7b were the most active, whereas compound 2c showed the highest MG_MD value (-5.66).

Item Type:Article
ID Code:4475
Uncontrolled Keywords:5,7-Diamino-3-phenyl-2-benzylamino, 2-phenoxy and 2-phenylthio substituted quinoxalines, antitumor activity
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier Masson
Copyright Holders:© 2008 Elsevier Masson SAS
Deposited On:02 Sep 2010 12:44

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