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Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry

Nieddu, Maria and Boatto, Gianpiero and Pirisi, Maria Antonietta and Baralla, Elena (2009) Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, Vol. 23 (19), p. 3051-3056. eISSN 1097-0231. Article.

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DOI: 10.1002/rcm.4219

Abstract

An analytical procedure for the simultaneous determination in human urine of several thioamphetamine designer drugs (2C-T and ALEPH series) is reported. The quantitative analysis was performed by liquid chromatography/tandem mass spectrometry and has been fully validated. The mass spectrometer was operated in positive-ion, selected reaction monitoring (SRM) mode. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid-phase extraction was introduced in the method as a clean-up step. The entire method was validated for selectivity, linearity, precision and accuracy. The method turned out to be specific, sensitive, and reliable for the analysis of amphetamine derivatives in urine samples. The calibration curves were linear over the concentration range of 1 to 100 ng mL-1 for all drugs with correlation coefficients that exceeded 0.996. The lower limits of detection (LODs) and quantification (LOQs) ranged from 1.2 to 4.9 ng mL-1 and from 3.2 to 9.6 ng mL-1, respectively.

Item Type:Article
ID Code:4451
Status:Published
Refereed:Yes
Uncontrolled Keywords:Amphetamines, chromatography, designer drugs, tandem mass spectrometry, urine
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Biologia animale
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Wiley
eISSN:1097-0231
Deposited On:31 Aug 2010 17:48

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