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Determination of p-methoxyamphetamine by capillary electrophoresis with diode array detection from urine and plasma samples

Nieddu, Maria and Boatto, Gianpiero and Sini, Loredana and Dessì, Giuseppina (2007) Determination of p-methoxyamphetamine by capillary electrophoresis with diode array detection from urine and plasma samples. Journal of Liquid Chromatography and Related Technologies , Vol. 30 (3), p. 431-438. eISSN 1520-572X . Article.

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DOI: 10.1080/10826070601084902

Abstract

In recent years, a number of newer designer drugs have entered the illicit drug market. The amphetamine derivatives represent the largest group of designer drugs. This paper describes a method for quantifying p-methoxyamphetamine in human plasma and urine by capillary electrophoresis with a diode array detector. Using an aqueous pH 2.5 phosphate buffer, CE analysis gave peaks with good symmetry and reproducible migration time. Under these experimental conditions, the p-methoxyamphetamine was resolved in 7 min and without interferences from biological matrices. The identification using the migration time was confirmed by UV spectra recorded with a diode array detector DAD (190-350 nm). Prior to CE-DAD analysis, a simple solid phase extraction (SPE) was used for sample cleanup. The main advantages of the present method lie in its simplicity and clean and reliable extraction from plasma and urine. The method was validated according to international guidelines.

Item Type:Article
ID Code:4445
Status:Published
Refereed:Yes
Uncontrolled Keywords:P-methoxyamphetamine (PMA), urine, plasma, capillary electrophoresis (CE)
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Taylor & Francis
eISSN:1520-572X
Deposited On:01 Sep 2010 09:49

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